DEBIO 1143
CAS No. 1071992-99-8
DEBIO 1143 ( AT-406;DEBIO1143;SM406;ARRY-334543;D1143 )
产品货号. M10293 CAS No. 1071992-99-8
DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥421 | 有现货 |
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5MG | ¥689 | 有现货 |
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10MG | ¥1077 | 有现货 |
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25MG | ¥2373 | 有现货 |
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50MG | ¥4479 | 有现货 |
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100MG | ¥6359 | 有现货 |
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500MG | ¥11259 | 有现货 |
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1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DEBIO 1143
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
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产品描述DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively; effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines; effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors.Ovarian Cancer Phase 2 Clinical
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同义词AT-406;DEBIO1143;SM406;ARRY-334543;D1143
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通路Others
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靶点Other Targets
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受体cIAP1-BIR3;cIAP2-BIR3;XIAP-BIR3
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研究领域Cancer
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适应症Ovarian Cancer
化学信息
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CAS Number1071992-99-8
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分子量561.73
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分子式C32H43N5O4
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纯度>98% (HPLC)
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溶解度DMSO: 93 mg/mL (165.6 mM); Ethanol: 93 mg/mL (165.6 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4
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化学全称(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cai Q, et al. J Med Chem. 2011 Apr 28;54(8):2714-26.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10;6(35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14;8(1):17862.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10;6(35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14;8(1):17862.
产品手册
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