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DEBIO 1143

CAS No. 1071992-99-8

DEBIO 1143 ( AT-406;DEBIO1143;SM406;ARRY-334543;D1143 )

产品货号. M10293 CAS No. 1071992-99-8

DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥421 有现货
5MG ¥689 有现货
10MG ¥1077 有现货
25MG ¥2373 有现货
50MG ¥4479 有现货
100MG ¥6359 有现货
500MG ¥11259 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    DEBIO 1143
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
  • 产品描述
    DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively; effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines; effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors.Ovarian Cancer Phase 2 Clinical
  • 同义词
    AT-406;DEBIO1143;SM406;ARRY-334543;D1143
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    cIAP1-BIR3;cIAP2-BIR3;XIAP-BIR3
  • 研究领域
    Cancer
  • 适应症
    Ovarian Cancer

化学信息

  • CAS Number
    1071992-99-8
  • 分子量
    561.73
  • 分子式
    C32H43N5O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 93 mg/mL (165.6 mM); Ethanol: 93 mg/mL (165.6 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4
  • 化学全称
    (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Cai Q, et al. J Med Chem. 2011 Apr 28;54(8):2714-26.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10;6(35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14;8(1):17862.
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